Treatment of Young White Mice Infected with Leptospira icterohaemorrhagiae with Immune Serum

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Abstract
Infectecd mice were1 treated by subsequent administration of normal rabbit serum, serum from patients convalescent from Weil''s disease, immune1 rabbit, serum and plasma and cone, immune rabbit serum. Normal rabbit serum failed to alter the course of leplospirosis in mice; the other materials were founel to be of value. When treatment was instituted em or before1 the1 4th day of infection 95.7% of 238 infecteel mice1 recovered; when treatment was delayed until the oth day only 50% of 48 mice1 survived; no recoveries were noted when serum was withheld until the1 6th day following infection. Only 2 of 60 mice1 given normal rabbit serum recovered from infection with L. icterohaemorrhagiae .