Stereocontrolled Synthesis of 2′-α-C-Branched Nucleoside Analogues and their Incorporation into Oligodeoxyribonucleotides
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (09) , 677-679
- https://doi.org/10.1055/s-1993-22569
Abstract
The stereoselective synthesis of 2′-α-C-branched nucleosides by a radical addition reaction is described. These new nucleosides were incorporated into oligodeoxyribonucleotides. Measurement of melting temperatures (Tm) of DNA/RNA duplexes and the nuclease resistance of these oligoribodeoxynucleotides are presented.Keywords
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