Reduced Cerebrovascular CO 2 Reactivity in CADASIL
- 1 January 2001
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Stroke
- Vol. 32 (1) , 17-21
- https://doi.org/10.1161/01.str.32.1.17
Abstract
Background and Purpose—Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukencephalopathy (CADASIL) is a hereditary angiopathy caused by mutations in Notch3. Cerebral microvessels show an accumulation of granular osmiophilic material in the vicinity of degenerating vascular smooth muscle cells. To study cerebrovascular function in CADASIL, we performed measurements on cerebral hemodynamics by using transcranial Doppler sonography. Methods—Middle cerebral artery (MCA) mean blood flow velocity (MFV), cerebrovascular CO2 reactivity, and the resistance index were measured by bilateral transcranial Doppler sonography in 29 CADASIL individuals (mean age, 49.0±2.4 years) and an equal number of age- and sex-matched control subjects. Results—Compared with control subjects, CO2 reactivity was reduced in CADASIL (33.4±2.7% versus 45.3±3.0%; P<0.01). This difference remained significant when only nondisabled CADASIL individuals (Rankin=0, n=21) were included in the analysis (P<0.05). CO2 reacti...Keywords
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