Flexible synthetic approach to histrionicotoxin congeners. Formal total synthesis of (±)-perhydrohistrionicotoxin
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1421-1425
- https://doi.org/10.1039/p19830001421
Abstract
Conversion of 1-benzyl-1-azaspiro[5.5]undec-7-en-9-one (7), readily available using simple organoiron chemistry, in six steps into (±)-depentylperhydrohistrionicotoxin (3) is reported. This compound has been previously reported as an intermediate for synthesis of (±)-perhydrohistrionicotoxin.Keywords
This publication has 2 references indexed in Scilit:
- Total Synthesis and Electrophysiological Properties of Natural (−)‐Perhydrohistrionicotoxin, its Unnatural (+)‐Antipode and their 2‐Depentyl AnalogsHelvetica Chimica Acta, 1982
- Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.Proceedings of the National Academy of Sciences, 1977