RADIOIODINE VOLATILIZATION FROM REFORMULATED SODIUM-IODIDE I-131 ORAL SOLUTION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (5) , 477-479
Abstract
By changing the pH and adding buffers, antioxidants and stabilizers to a NaI (I-131) oral solution, a reduced radioiodine volatilization was claimed by a commercial supplier of radioiodinated pharmaceuticals commonly used in thyroid cancer therapy. The airborne radioactivity volatilized from the reformulated sodium iodide solution was compared with airborne volatization from a previous formulation. Air samples were obtained from the fume hood''s exhaust stack during initial venting and from the breathing zones of physicians and technologists administering the solution to the patient. Analysis of the air samples indicates significant reduction in the airborne radioiodine following initial venting of the solution vial and during patient administration. A decline occurred in the I-131 thyroid burdens for occupationally exposed personnel handling the reformulated sodium iodide solutions.

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