Nucleosides and Nucleotides. Part 19. On Detritylation with Zinc Bromide in Oligonucleotide Synthesis
- 15 December 1982
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 65 (8) , 2472-2475
- https://doi.org/10.1002/hlca.19820650815
Abstract
Zinc bromide has been shown by several groups of workers to be a useful reagent in the removal of trityl protecting groups from nucleotides. An attempt is made here to establish optimum conditions for the reaction, a strange observation is reported, and a novel workup via a soluble, lipophilic zinc complex is described.Keywords
This publication has 7 references indexed in Scilit:
- Dialkyl aluminium chloride: a reagent for removal of trityl group from trityl ethers of deoxynucleosides, deoxynucleotides, and oligodeoxynucleotidesTetrahedron Letters, 1982
- Selective N-deacylation of N,O-protected nucleosides by zinc bromideTetrahedron Letters, 1981
- Nucleosides and Nucleotides. Part 17. A simple preparation of protected deoxynucleoside‐3'‐phosphatesHelvetica Chimica Acta, 1981
- Synthesis of deoxyoligonucleotides on a polymer supportJournal of the American Chemical Society, 1981
- The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosidesTetrahedron Letters, 1980
- The triphenylmethyl (trityl) group and its uses in nucleotide chemistryTetrahedron Letters, 1980
- Studies in the stereochemistry of zinc(II). IV. Complexes of zinc halides with heterocyclic basesAustralian Journal of Chemistry, 1966