PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase
Top Cited Papers
Open Access
- 19 October 2006
- journal article
- Published by American Society of Hematology in Blood
- Vol. 109 (3) , 862-867
- https://doi.org/10.1182/blood-2006-07-028829
Abstract
Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogeneKeywords
This publication has 90 references indexed in Scilit:
- Germline Missense Mutations Affecting KRAS Isoform B Are Associated with a Severe Noonan Syndrome PhenotypeAmerican Journal of Human Genetics, 2006
- Germline KRAS mutations cause Noonan syndromeNature Genetics, 2006
- Diversity and Functional Consequences of Germline and Somatic PTPN11 Mutations in Human DiseaseAmerican Journal of Human Genetics, 2006
- Germline mutations in HRAS proto-oncogene cause Costello syndromeNature Genetics, 2005
- Diverse Biochemical Properties of Shp2 MutantsJournal of Biological Chemistry, 2005
- A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathyEuropean Journal of Pediatrics, 2005
- Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemiaJournal of Human Genetics, 2005
- Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndromeJournal of Medical Genetics, 2005
- Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorderBlood, 2004
- Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancersNature Genetics, 2002