The Influence of Avoidance-Learning Stress on Resistance to Coxsackie B Virus in Mice

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Abstract
Summary: Coxsackie virus B1 infections were induced in mice subjected to avoidance-learning stress and in unstressed controls. Infected, stressed mice were more susceptible than infected, unstressed mice as manifested by weight loss and deaths during the 1st week after inoculation, and as an increased dispersion in weight changes about 5 weeks after inoculation. A significantly higher virus titer could be demonstrated in the pancreas, liver, heart and muscle of stressed mice as compared to unstressed mice.