Obstructive Lung Disease and α 1 -Antitrypsin Deficiency Gene Heterozygosity
- 29 August 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3896) , 899-901
- https://doi.org/10.1126/science.165.3896.899
Abstract
The phenotypes of serum α 1 -antitrypsin were determined by antigen-antibody crossed electrophoresis. There were five homozygotes and 25 heterozygotes for the deficiency gene found in a group of 103 patients with obstructive lung disease. The frequency of heterozygotes was 14 and 9 percent in two control groups with different mean ages of 36 and 80. There was only one heterozygote among 39 healthy males over 70 years of age. Heterozygosity may be a predisposing factor in chronic obstructive lung disease, especially in the male population.Keywords
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