Nonsteroidal Anti-Inflammatory Drugs

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Abstract
IndomethacinIndomethacin (Indocin), although very different chemically from phenylbutazone, shares much of its therapeutic spectrum. It has proved at least in vitro to be a very potent anti-inflammatory drug. Its mode of action is still uncertain, but it appears to be one of the most effective inhibitors of prostaglandin biosynthesis that is available for human use.1 Considering the fact that prostaglandins have been demonstrated in most organ systems and have been shown to have potent local physiologic effects, it is remarkable that indomethacin does not have much broader and more complex actions than have so far been apparent.The documented . . .

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