Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species
- 1 June 1974
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (6) , 2169-2173
- https://doi.org/10.1073/pnas.71.6.2169
Abstract
The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [ 3 H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.Keywords
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