Preliminary in vitro Studies of Melanophore-Principle Activity of the Pituitary Gland.

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Abstract
(1) In vitro experiments indicate that one of the biological mechanisms of the melanophore hormone is that of an accelerator of an oxidase system such as tyrosine-tyrosinase. (2) The pressor hormone, and perhaps the oxytocic hormone also, act to inhibit this oxidase system. (3) Melanophore hormone has been obtained from anterior sperm whale pituitary which results in a black coloration of hypophysectomized frogs when 1 cc of a 1 × 10-6 dilution of this hormone is injected. The black coloration persists for at least 24 hours.

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