Paradoxical effect of ethanol on liver lipogenesis in the genetically-obese Zucker rat

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Abstract
1. Sixteen obese (fa/fa) Zucker rats, sixteen lean (Fa/-)Zucker rats and sixteen Wistar rats, all male rats aged 7–8 weeks, were given either a control (C) diet containing no ethanol or an ethanol (E) diet in which 36% of the energy was supplied by ethanol, for a period of 4 weeks.2. The activities of glucose-6-phosphate dehydrogenase (EC 1.1.1.49), glucose-6-phosphatase (EC 3.1.3.9) and glycerol kinase (EC 2.7.1.30) and the glycogen content in the livers of obese (fa/fa)rats were lower in animals given diet E than in those given diet C. As a result, hepatic lipogenesis and fatty degeneration of the liver were reduced in obese (fa/fa) rats given diet E.
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