Hepatic Necrosis After Enflurane Anesthesia
- 8 April 1974
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 228 (2) , 158
- https://doi.org/10.1001/jama.1974.03230270018011
Abstract
To the Editor.— Halogenated agents, if and when they cause this type of symptomatology, usually manifest their effects in five to seven, not 19, days.1Chlorpromazine causes a selective rise in serum alkaline phosphatase activity.2 Many other possible etiologies of hepatic necrosis are found in this patient. Exacerbation of the process causing the cirrhosis, possible hypotension during gastrointestinal bleeding, and hepatitis secondary to blood transfusion. We feel that it is a disservice to implicate a new and useful anesthetic agent by the headline "Hepatic Necrosis After Enflurane Anesthesia," on a letter that makes unsupported suppositions.Keywords
This publication has 1 reference indexed in Scilit:
- Chlorpromazine hepatotoxicity manifested by a selective and sustained rise of serum alkaline phosphatase activityDigestive Diseases and Sciences, 1965