Letter: On the interaction of tetrodoxin with cholesterol monolayers.

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Abstract
Tetrodotoxin (TTX) caused expansion of cholesterol monolayers on a 0.15 M NaCl solution (free of phosphate buffer) and on tridistilled water subphases. The monolayer expansions were 2.2 and 1.6 A2/molecule, respectively. Two alternative interpretations of the toxin-monolayer interaction proposed were that cholesterol may be a component of the actual receptor or that the TTX (and saxitoxin) receptor may share some chemical features with the monolayer, the interaction being a property of the monolayer rather than of the individual cholesterol molecule. Differences found between the interactions of the toxins with the monolayer and with the receptor (e.g., disagreements of the dissociation constants and of the effects of pH), made the latter explanation the more likely. ["A" is not defined.].

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