The effect of ethanol on the ventilatory responses mediated by the peripheral chemoreceptors in man
- 1 May 1978
- journal article
- research article
- Published by Springer Nature in Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Vol. 25 (3) , 181-190
- https://doi.org/10.1007/bf03004877
Abstract
The ventilatory responses mediated by the central and peripheral chemoreceptors were separately assessed in eight healthy volunteers before and after the oral ingestion of ethanol in a dose of 0.75 ml/kg. No significant depression of the central response was observed, but a significant depression of the peripheral response was observed at 25 and 95 minutes after the consumption of ethanol. The peripheral chemoreceptor stimulus was the simultaneous increase of hypoxia and hypercapnia and this novel method is described. La réponse respiratoire réflexe initiée par les chémorécepteurs centraux et périphériques a été étudiée de façon séparée chez huit volontaires en bonne santé, avant et après ingestion orale de 0.75 ml/kilo ďalcool éthylique. On n’a pas observé de dépression significative du mécanisme central, mais une dépression significative de la réponse périphérique a été observée, 25 et 95 minutes après ingestion de ľalcool. Comme stimulus des chémorécepteurs périphériques, on a utilisé une hypoxie et une hypercapnie simultanée et croissante. Cette nouvelle méthode est décrite.Keywords
This publication has 13 references indexed in Scilit:
- A mathematical model of the chemoreflex control of ventilationPublished by Elsevier ,2003
- THE EFFECT OF HALOTHANE AND THIOPENTONE ON VENTILATORY RESPONSES MEDIATED BY THE PERIPHERAL CHEMORECEPTORS IN MANBritish Journal of Anaesthesia, 1976
- Effect of Ethanol on the Ventilatory Responses to Oxygen and Carbon Dioxide in ManClinical Science, 1975
- A clinical method for assessing the ventilatory response to hypoxia.Published by Elsevier ,1974
- Acute respiratory effects of ethanol in manClinical Pharmacology & Therapeutics, 1973
- Respiratory effects of ethyl alcohol intoxicationPublished by American Medical Association (AMA) ,1972
- The chemical regulation of ventilationAnaesthesia, 1971
- The Effect of Halothane on Ventilatory Responses Mediated by the Peripheral ChemoreceptorsClinical Science, 1971
- Hypoxic ventilatory drive in normal manJournal of Clinical Investigation, 1970
- Alcohol Distribution in the Vascular System: Concentration of Orally Administered Alcohol in Blood from Various Points in the Vascular System, and in Rebreathed Air, During AbsorptionQuarterly Journal of Studies on Alcohol, 1964