Muscle Glycogen Synthetase in Patients with Diabetes Mellitus
- 1 January 1972
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 29 (2) , 237-242
- https://doi.org/10.3109/00365517209081081
Abstract
An inverse relationship between glycogen content and synthetase I activity (% of total) was previously found in human muscle tissue. We have found basal content of glycogen and synthetase I activity in relation to the glycogen content in muscle of diabetic patients to be significantly lower than in normals. Treatment with insulin restored the relationship between I activity and glycogen towards normal, total activity remaining unchanged. Glycogen depletion by exercise increased I activity in diabetic patients, but to a lower extent than in normals.Keywords
This publication has 15 references indexed in Scilit:
- Control Mechanisms for the Synthesis of Glycogen in Striated MusclePublished by Springer Nature ,1971
- The influence of insulin and epinephrine on adenosine 3′,5′-phosphate and glycogen transferase in muscleBiochimica et Biophysica Acta (BBA) - General Subjects, 1969
- Udpglucose: α-1,4-glucan α-4-glucosyltransferase in heart regulation of the activity of the transferase in vivo and in vitro in rat. A dissociation in the action of isulin on transport and on transferase conversionBiochimica et Biophysica Acta (BBA) - General Subjects, 1969
- Effects of exercise on glycogen synthetase in red and white skeletal muscleLife Sciences, 1968
- UDP-glucose-glucan glucosyl-transferase activity of polymorphonuclear leukocytes from diabetic subjectsDiabetologia, 1968
- Effects of insulin treatment on muscle 3′,5′-cyclic adenylate levels in vivo and in vitroBiochimica et Biophysica Acta (BBA) - General Subjects, 1967
- Muscle Glycogen in Man Determined in Needle Biopsy Specimens Method and normal valuesScandinavian Journal of Clinical and Laboratory Investigation, 1967
- Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in ManNature, 1966
- Muscle Glycogen in Juvenile Diabetes before and during Treatment with InsulinNature, 1963
- Rapid Specific Method for Determination of Aldosaccharides in Body FluidsNature, 1959