ENHANCING ABSORPTION IN THE CANINE SHORT BOWEL SYNDROME BY INTESTINAL PACING

  • 1 January 1980
    • journal article
    • research article
    • Vol. 88  (2) , 281-286
Abstract
Pacing the small bowel backward in dogs with the short bowel syndrome was investigated to determine whether intestinal absorption could be enhanced. In 5 dogs the aborad one third of the small bowel and the entire colon were removed and an ileorectostomy was established. The duodenum was transected and reanastomosed 10 cm from the pylorus to facilitate pacing and cannulas were inserted in the intestine at 15, 110 and 115 cm for perfusion, sample collection, and balloon occlusion, respectively. Recording and stimulating electrodes were affixed to the bowel between perfusion and collection cannulas. In 4 or more trials in each dog, an isotonic perfusate of glucose (138 mM), NaCl (76 mM) and 3H-polyethylene glycol was introduced via the proximal cannula at 2.9 ml/min and effluent collected from the distal cannula for 3 h. During h 2, electrical stimuli were applied to the distal end of the perfused segment to drive the pacesetter potentials of the perfused segment backward. Pacing decreased markedly the output of water, glucose, Na and K and increased the concentration of polyethylene glycol in the effluent. Retrograde electrical pacing apparently increased small intestinal absorption of water, glucose and Na and decreased output of K in dogs with short bowel syndrome.

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