[99mTc]Tricine: a Useful Precursor Complex for the Radiolabeling of Hydrazinonicotinate Protein Conjugates
- 1 September 1995
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 6 (5) , 635-638
- https://doi.org/10.1021/bc00035a020
Abstract
The stannous reduction of [99mTc]pertechnetate in the presence of tricine results in the formation of the new labeling precursor complex [[99m-Tc]tricine. This complex has improved efficacy for the 99mTc labeling of hydrazinonicotinate-modified IgG compared to [99mTc]glucoheptonate. FAB mass spectral analysis of the product formed by the reaction of [TcOCl4](-1) with tricine indicates the formation of [TcO(tricine x 2H)2](-1).Keywords
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