Compound 48/80‐induced permeability change in liposomal membrane
- 24 January 1983
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 151 (2) , 219-222
- https://doi.org/10.1016/0014-5793(83)80073-8
Abstract
The action of compound 48/80 (a mixture of condensation products of p‐methoxy‐N‐methylphenethylamine with formaldehyde) on liposomal membranes was studied by means of K+‐loaded liposomes and a K+ ion‐selective electrode. Prompt efflux of K+ was detected when 48/80 was added to the negatively charged liposome suspension, while the monomer of 48/80, p‐methoxy‐N‐methylphenethylamine, did not release K+ from the same liposomes. The mechanism for the action of 48/80 is discussed in comparison with that of a polymyxin, well known as an antibiotic acting on bacterial membranes.Keywords
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