Arterial or mixed venous lactate measurement in critically ill children. Is there a difference?

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Abstract
Seven critically ill children had simultaneous measurement of whole blood lactate concentrations obtained from a systemic arterial and mixed venous (pulmonary artery) site. An excellent correlation was found (r= 0.995). The mean difference between arterial and mixed venous values was 0.02 mmol/ 1 and the limits of agreement (±0.22) were —0.20 to 0.24. The differences found were clinically insignificant (two‐tailed paired Student's t‐test; p= 0.36) and therefore support the continued use of arterial sampling for blood lactate measurement.