Periarteritis in Rats Given Single Injection of 4'-Fluoro-10-methyl-1,2-benzanthracene.

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Abstract
A single subcutaneous injection of 2.14 mg of the compound in albino rats produced a severe and fatal periarteritis in 4 to 8 weeks. Similar lesions were seen after injection of 1/2 as much of this hydrocarbon, but they developed more slowly. Equivalent levels of 10-methyl-l,2-benzanthracene or the solvent alone were ineffective. The most severe lesions were observed in pulmonary arteries; this finding is in accord with the cyanotic conditions of some of the rats. Hyaline necrotic lesions were observed in renal arterioles and glomerular capillaries. A possible immunological basis for these lesions is discussed.