Biotransformation of 2-(4-methoxybenzyl)-1-cyclohexanone by means of Saccharomyces cerevisiae
- 1 January 1987
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 52 (9) , 2326-2337
- https://doi.org/10.1135/cccc19872326
Abstract
Biotransformation reduction of 2-(4-methoxybenzyl)-1-cyclohexanone was investigated. A method was elaborated for the preparation of some diastereoisomeric alcohols derived from the racemic title ketone and for the determination of the products obtained. The study resulted in the synthesis of cis-(1S,2S)-(+)-2-(4-methoxybenzyl)-1-cyclohexanol and trans-(1S,2R)-(+)-2-(4-methoxybenzyl)-1-cyclohexanol in optical purity of at least 91.6 ± 1.0% and 97.5 ± 1.0%, respectively.Keywords
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