Zur Theorie der Thiaminpyrophosphat-Wirkung, V. Die Funktion der beiden Pyrimidin-N-Atome
- 1 January 1967
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 348 (Jahresband) , 501-505
- https://doi.org/10.1515/bchm2.1967.348.1.501
Abstract
Replacement of the pyrimidine ring of thiamine pyrophosphate by a pyridine ring results in two possible analogues, in which either N-3 (analogue I) or N-1 (II) is replaced by CH. Both analogues were synthesised and their enzymatic activity was studied. Analogue I exhibited coenzyme activity and had a demonstrable affinity for the apoenzyme. Therefore N-1 acts as a binding site for the active center, while N-3 has essentially no importance for the mechanism of action of thiamine pyrophosphate.This publication has 9 references indexed in Scilit:
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