Recent advances in cellular Ca2+homeostasis: implications to altered regulations of cellular Ca2+ and Na+–H+ exchange in essential hypertension
- 1 September 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Cardiology
- Vol. 11 (5) , 477-482
- https://doi.org/10.1097/00001573-199609000-00005
Abstract
This review covers the role of the sarco(endo)plasmic reticulum in regulating Ca2+ influx across the plasma membrane, the role of cytosolic free Ca2+ in modulating mitochondrial function, and the role of the plasma membrane in regulating sarco(endo)plasmic reticulum Ca2+, focusing on recent findings that shed a new light on cellular Ca2+ regulation. Mechanisms of interactions among the sarco(endo)plasmic reticulum, mitochondria, and the plasma membrane are discussed with a view to explain the lack of consensus regarding the relationship between the cytosolic free Ca2+ and blood pressure, and the enigmatic behavior of the Na(+)-H+ exchanger in blood cells (primarily platelets and lymphocytes) from patients with essential hypertension.Keywords
This publication has 0 references indexed in Scilit: