Distribution, Excretion, and Metabolism of p-Phenylenediamine in Rats

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Abstract
The distribution, excretion and metabolism of p-phenylenediamine, a constituent of oxidative hair dye, was studied after i.p. administration of [14C]p-phenylenediamine (1.5 mg/kg) to male rats. In tissues other than the small and large intestines, the highest concentration of radioactivity was found at 1 h, followed by a rapid decrease in concentration. Only small amounts of radioactivity were found in the tissues 48 h after administration. The low levels of radioactivity in tissues, together with the large amounts of radioactivity found in the intestinal tract and in urine, indicated the rapid excretion of administered p-phenylenediamine. Within 24 h after administration, 69% of the administered radioactivity was excreted in the urine, 29% in the feces, and 26% of the i.v. administered radioactivity was excreted in the bile. TLC of the urine indicated the presence of several urinary metabolites. The reverse isotope dilution method identified 1 of the metabolites as N,N''-diacetyl-p-phenylenediamine, which accounted for 30% of the radioactivity in the urine.

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