PROPHYLACTIC IMMUNIZATION AND SPECIFIC THERAPY OF EXPERIMENTAL PNEUMONIC PLAGUE
- 1 January 1948
- journal article
- research article
- Published by Elsevier
- Vol. 57 (4) , 312-321
- https://doi.org/10.1164/art.1948.57.4.312
Abstract
Intranasal instillation of 2000-25,000 virulent plague bacilli produced in mice, guinea pigs and cotton rats a primary pneumonia which was anatomically indistinguishable from that observed in man. Active immunization with avirulent strains of Pasteurella pestis or chemically killed plague bacilli conferred on mice and guinea pigs definite protection against the intranasal infection. Sulfonamides, unless combined with antiplague serum, were not very effective in exptl. pneumonic plague. Streptomycin, in 5-mg. amts., was an effective therapeutic agent in over 90% of experimentally infected mice.Keywords
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