Efficient Catalyst for the Suzuki−Miyaura Coupling of Potassium Aryl Trifluoroborates with Aryl Chlorides
- 25 June 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (16) , 2649-2652
- https://doi.org/10.1021/ol0491686
Abstract
Palladium-catalyzed Suzuki−Miyaura cross-coupling reactions of aryl- and heteroaryl chlorides with potassium aryl- and heteroaryltrifluoroborates have been accomplished with the supporting ligand S-Phos in good to excellent yield. Hindered biaryls and substrates containing a variety of functional groups can be prepared. Suzuki−Miyaura couplings of a 3-pyridyl boron-based nucleophile with aryl- and heteroaryl chlorides proceed in good to very good yield.Keywords
This publication has 3 references indexed in Scilit:
- A Rationally Designed Universal Catalyst for Suzuki–Miyaura Coupling ProcessesAngewandte Chemie International Edition in English, 2004
- Advances in the Negishi CouplingAustralian Journal of Chemistry, 2004
- Versatile Catalysts for the Suzuki Cross-Coupling of Arylboronic Acids with Aryl and Vinyl Halides and Triflates under Mild ConditionsJournal of the American Chemical Society, 2000