Role of Extended Culture Time on Synergy of Fluconazole and Human Monocyte-Derived Macrophages in Clearing Candida albicans
Open Access
- 1 October 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 174 (4) , 888-890
- https://doi.org/10.1093/infdis/174.4.888
Abstract
Possible enhanced candidacidal synergy of fluconazole and human monocyte-derived macrophages by extended culture time was studied. Synergistic candidacidal activity increased from 1 day to 3 days and was maximal at 6 days. Enhanced synergistic candidacidal activity at 144 h was observed over a l0-fold challenge dose range. Enhanced synergy with culture time was seen with fluconazole-susceptible and -resistant isolates of Candida albicans. These findings emphasize the importance of dosage and an adequate period of therapy.Keywords
This publication has 0 references indexed in Scilit: