Acute effect of methamphetamine on heme oxygenase activity and on cytochrome P-450 content in the liver of female rats.

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Abstract
After a single treatment with d-methamphetamine (philopon, an addictive central stimulant) at a dose of 8 mg/kg in 10 wk old female Wistar rats, heme oxygenase activity was enhanced at 3 h and reached its peak level at 12 h, but cytochrome P-450 content showed the lowest level at 12 h. Activity of .delta.-aminolevulinic acid synthetase was unaffected. After 24 h all measured parameters returned to nearly initial levels at zero time. The pretreatment with cycloheximide blocked the increase of heme oxygenase activity in philopon-treated animals.