Alternative Anti-Inflammatory Drugs in the Treatment of Bronchial Asthma

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Abstract
Recent investigations into the pathogenesis of asthma have highlighted the importance of airway inflammation in this disorder. Although currently approved anti-inflammatory compounds including glucocorticoids and antireleasing agents have become first-line therapy in the treatment of asthma, several alternative anti-inflammatory agents have been evaluated, especially for patients who are steroid-dependent. These agents—including gold salts, methotrexate, cyclosporin, and others—are postulated to have anti-inflammatory mechanisms of activity. Although some patients have improved on these agents, drug-related side effects have been a significant problem, and generalized use of these agents is not appropriate at this time. This article reviews the rationale for use of and accumulated experience with these drugs.

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