Toxicity Study of Sodium Metrizoate Containing Calcium and Magnesium

Abstract
Lesser disturbances in heart rate and arterial blood pressure were produced by carotid injection in the dog of a sodium metrizoate containing Ca and Mg than by a pure sodium metrizoate solution, supporting the concept that these bivalent ions reduce that portion of toxicity of an angiographic agent which is thought to be due to an excess of Na ions.