Clinical Usefulness of the Dye‐Injection Method for Diagnosing Premature Rupture of the Membranes in Equivocal Cases

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Abstract
Objective: In 1981, we preliminarily reported on the clinical value and safety of the intra‐amniotic dye (Phenol‐sulfonphthalein, PSP)‐injection method for diagnosing PROM. In the current study, through examination of 64 equivocal cases in the midtrimester of pregnancy, we investigated the clinical efficacy of the PSP test.Methods: In the present study we examined patients with equivocal PROM in their 14th week to 33rd week of gestation, whose findings were positive according to a combination of conventional diagnostic methods. The results of the PSP test and conventional diagnostic methods were compared with the final diagnosis of PROM.Results: The conventional diagnostic methods showed an accuracy rate of 63.9%–70.5%, in contrast to the PSP test, which had a 100%‐accuracy rate (p < 0.001).Conclusion: Using the PSP test in combination with amnioscopy, we have established a method of differentially diagnosing PROM. We have reconfirmed the clinical efficacy of the PSP test in 64 equivocal PROM cases.

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