Ethanol, Lipase Activity, and Serum-Lipid Level

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Abstract
Ethanol increases and prolongs the hyperlipemia following a fat load (corn oil). This does not seem to be due to changes in fat absorption or removal; studies done in man failed to show any effect of ethanol (in vivo and in vitro) on the postheparin lipoprotein-lipase activity. The data presented here and data from the literature suggest the importance of many mechanisms in the explanation of the marked hyperlipemia seen after the ingestion of corn oil plus ethanol: 1) an increased amount of NEFA brought to the liver (from hydrolyzed corn oil and mobilized fat stores), 2) an increased percentage of incorporation of NEFA into triglycerides, 3) an increased synthesis and decreased oxidation of fatty acid by the liver, 4) an increased amount of α-glycerophosphate, and 5) an increased release of lipoprotein from the liver.