Effects of Medicinal Plants Extracts on Sialidase Activity

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Abstract
Anti-sialidase activity was studied as part of a research on pharmacological actions of medicinal plants. Kakkon-to (extracted granular 2.5 g 20 ml H2O) showed sialidase inhibition activity (64.4%). Taiso, Mao, Keihi and Shakuyaku, which were constituents of Kakkon-to, inhibited sialidase activity and Mao showed the strongest inhibition effects. The medicinal plants extracts showing the inhibition of sialidase contain various tannins. The anti-sialidase activity of tannic acid varied according to the concentration of tannic acid and galloylglucoses (1,2,6-tri-, 1,2,3,6-tetra- and 1,2,3,4,6-pentagalloyl-.beta.-D-glucose) found in Gobaishi and Boshokushi. Those extracts showed very strong inhibition, depending on the number of galloyl groups but without relation to gallic acid and glucose. Effects of galloylglucoses on Vero cells were examined. Vero cells were impaired at the concentration of 10 .mu.g ml. Anti-sialidase activity of flavones was examined and among flavones, kaempferol showed the strongest inhibition effects.

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