The neuroparalytic accidents of antirabies vaccination

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Abstract
Review of the literature and clinical observations indicate that about 1 case in every 800 given antirabies treatments may develop neuroparalytic symptoms which may end fatally. These symptoms fall into 2 groups: an acute perivascular myelinoclasis and a polyradicu-loneuronitis. ACTH therapy helps greatly in cases of the 1st type, but is of doubtful value in those of the 2d type. Anti-histamine (especially benadryl) proved to be of no value in the treatment of either type in the present series of cases.