ULTRASTRUCTURAL CHANGES OF OLIGODENDROGLIA AND MYELIN SHEATHS INDUCED BY ETHIDIUM BROMIDE

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Abstract
Yajima K. & Suzuki K. (1979) Neurobiology and Applied Neuropathology5, 49–62Ultrastructural changes of oligodendroglia and myelin sheaths induced by ethidium bromideIntracisternal injection of ethidium bromide, an inhibitor of mitochondria associated RNA, DNA and protein synthesis, produced status spongiosus in the subpial surface of the CNS of rats. Ultrastructurally, numerous intra‐myelink vacuoles and prominent degenerative changes of oligodendroglia were observed. The vacuoles were formed between the myelin lamellae by splitting of the intraperiod lines, between the axolemma and the innermost myelin lamellae, and/or between the inner tongue of oligodendroglia and myelin lamellae. In the degenerating oligodendroglia, proliferation and alteration of the endoplasmic reticulum were prominent. In places, altered membranes of the endoplasmic reticulum formed concentrical scroll‐like structures. These ultrastructural changes in ethidium bromide treated rats were compared with other similar previously described changes in animals treated with TET, cuprizone, hexachlorophene, hypocholesterolaemic drugs and actino‐mycin D.