Uveitis Associated With Topical β-Blockers

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Abstract
Objective:To assess the incidence of uveitis associated with topical β-blockers.Design:Retrospective cohort study.Setting:A computerized database of a health maintenance organization was used to identify patients who were prescribed metipranolol or other β-blockers.Patients:Two groups: 1928 patients using 0.3% metipranolol and 3903 patients using other β-blockers.Main Outcome Measure:Cases of uveitis were identified by noting a prescription of a topical corticosteroid and then conducting a chart review.Results:No cases of uveitis were identified among the 5831 patients. The upper limits of the 95% confidence intervals for the incidence of uveitis in cohorts of this size are 1.87 cases per 1000 person-years of exposure for metipranolol and 1.38 for other β-blockers.Conclusion:Drug-induced uveitis from metipranolol or other β-blocker administration is a rare event, even if a causal relationship exists.

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