Urinary Zinc Excretion in Patients with Urolithiasis

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Abstract
Urinary zinc, calcium, creatinine and osmolar excretion per 24 hours was measured in 21 healthy subjects and 49 patients with urolithiasis. Urinary zinc excretion in kidney-stone formers was lower than in healthy subjects, but the difference was not statistically significant. In healthy subjects, there was a normal relationship between urinary zinc excretion and urine volume, creatinine and osmolar excretion, which was not found, with some exceptions, in the groups of patients. There was no relationship between urinary zinc and calcium excretion in healthy subjects or in patients with normocalciuria or hypercalciuria. A possible role of relative hypozincuria in kidney-stone formation in patients with hypercalciuria and/or hyperoxaluria is suggested.

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