Intra‐Arterial Infusion of the Chemotherapeutic Agents Methotrexate and “Epodyl” in Patients with Advanced Localized Carcinomata Recurrent after Radiotherapy

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Abstract
Amongst the significant developments in the use of chemotherapeutic agents in the treatment of advanced malignant disease during the past decade has been direct intra‐arterial infusion of drugs to the diseased area. Occasional cases of dramatic improvement have been reported, but most of these have been seen in tumours not previously irradiated. Yet most patients referred for such treatment have disease which has recurred after other forms of therapy, including radiotherapy, have been exhausted. This paper describes experience in the use of intra‐arterial infusion of anticancer chemotherapeutic agents in two groups of patients with advanced tumours recurrent after previous radiotherapy. First is recorded experience with methotrexate infusion, followed by experience with a newer, rapidly acting alkalating agent, “Epodyl”.