RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis
- 6 February 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 560 (1-3) , 81-85
- https://doi.org/10.1016/s0014-5793(04)00074-2
Abstract
It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.Keywords
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