Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
Top Cited Papers
- 20 December 2012
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 339 (6118) , 456-460
- https://doi.org/10.1126/science.1230835
Abstract
Bat Genomes: Bats are of great interest because of their ability to fly and as hosts for infectious disease. Zhang et al. (p. 456 , published online 20 December) sequenced the genomes of two distantly related bat species, David's Myotis and Black flying fox. Analysis of the two genomes revealed likely changes that accompanied the evolution of bats, including selection for increased expression of genes involved in the oxidative phosphorylation pathway needed to generate the energy required for flight. Furthermore, while some immune genes have been lost, others are under positive selection, which may potentially explain bats' status as viral reservoirs.This publication has 52 references indexed in Scilit:
- Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNasesProceedings of the National Academy of Sciences, 2012
- Genome sequencing reveals insights into physiology and longevity of the naked mole ratNature, 2011
- IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint functionThe EMBO Journal, 2010
- Adaptive evolution of energy metabolism genes and the origin of flight in batsProceedings of the National Academy of Sciences, 2010
- Fast and accurate short read alignment with Burrows–Wheeler transformBioinformatics, 2009
- TopHat: discovering splice junctions with RNA-SeqBioinformatics, 2009
- Massive amplification of rolling-circle transposons in the lineage of the bat Myotis lucifugusProceedings of the National Academy of Sciences, 2007
- RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed modelsBioinformatics, 2006
- Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertionsProceedings of the National Academy of Sciences, 2006
- BLAT—The BLAST-Like Alignment ToolGenome Research, 2002