Isoproterenol dose-outflow facility response relationships in the vervet monkey

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Abstract
Total outflow facility was measured by 2-level constant pressure anterior chamber perfusion in surgically untouched vervet monkeys receiving intracameral infusions of mock aqueous humor without or with isoproterenol. Bolus dl-isoproterenol sulfate doses of 1-10 .mu.g, corresponding respectively to initial intracameral base concentrations of 2 .times. 10-5 M and 2 .times. 10-4 M, increased facility 30-50%; higher and lower bolus doses were ineffective, as were 0.1 and 1 g doses of 1-isoproterenol hydrochloride (4 .times. 10-6 M and 4 .times. 10-5 M base). Relatively maintained intracameral dl-isoproterenol concentrations of 2 .times. 10-7 M and 2 .times. 10-6 M or l-isoproterenol concentrations of 4 .times. 10-7 M to 4 .times. 10-5 M did not significantly increase facility, although there was great variability with the latter agent. Possible reasons for species, investigator, technique, and dosage-associated differences in results are discussed.