Lipid Metabolism of Young Female Rats Fed Diets Varying in Fat and Calories

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Abstract
The effect of diet on rate of synthesis of several lipids was studied using young female rats. Dietary variations were 1 or 20% cottonseed oil and 20% animal fat (lard and butter in equal amounts). Young adult and weanling animals were fed these diets for 4, 7 or 12 weeks, at which time each was given Na-1-C14-acetate. Amounts of serum and liver lipids and isotope incorporation were determined. Cholesterol synthesis was enhanced, whereas noncholesterol lipids were depressed by the higher amounts of fat. At 10 weeks the animals fed the higher level of fat had very high cholesterol activities with only slightly larger concentrations of cholesterol in the livers and serum. When food intake was restricted the rate of cholesterol metabolism was related to the amount of dietary or stored fat utilized for energy.