Immunoglobulins in myasthenia gravis: effect of human lymph IgG 3 and F(ab‘)2 fragments on a cholinergic receptor preparation from Torpedo marmorata*
- 1 April 1977
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 7 (2) , 115-119
- https://doi.org/10.1111/j.1365-2362.1977.tb01582.x
Abstract
Lymph IgG from patients with myasthenia gravis was shown to inhibit the binding of radio-labelled Naja naja siamensisα-neurotoxin to membrane fragments from the electric organ of Torpedo marmorata. This effect could be related to IgG subclass 3 and to the F(ab)2 fragment. These findings confirm the involvement of antibodies to postsynaptic structures in myasthenia gravis.Keywords
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