The Stereochemical Course of Nucleotidyl Transfer Catalysed by NAD Pyrophosphorylase
Open Access
- 1 April 1983
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 132 (1) , 117-120
- https://doi.org/10.1111/j.1432-1033.1983.tb07334.x
Abstract
NAD pyrophosphorylase catalyes nucleotidyl trasfer from adensone (R′‐[α‐17O]triphosphate to nicotinamide monocucledotide with inversion of configuration at the α‐P giving (S‐[17O]NAD+. The simplest interpretation of the observation is that the adenyly group is trasferred directly from ATP to the co‐substrate by an ‘in line’ mechanism. It is also shown that snake venom phosphodiesterase hydrolyses NAD+ regio‐specifically at the adenylyl terminus of the pyrophosphate bond.This publication has 28 references indexed in Scilit:
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