Multifactorial analysis of the outcome of 6430 cadaver kidney grafts

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Abstract
A total of 6430 cadaver kidney grafts performed within the network of France-Transplant between 1 January 1978 and 1 January 1989 were analyzed. Each case was examined comprehensively in regard to 12 variables. A multifactorial analysis (Cox regression) was used to determine the degree of association between each co-variate and the outcome of the graft. The results were evaluated by calculating relative risks of graft failure for each variable. A total of seven covariates appeared to influence graft survival significantly: the period of transplantation (P=10-8), retransplantations (P =0.003), age and sex of the donor (P=0.003 and 0.009 respectively), duration of pretransplant dialysis (P=0.03), pretransplant sensitization to HLA antigens (P=0.05), and matching for HLA-A, -B, and -DR loci (P=0.03). This last parameter has previously been reported as influencing the outcome of the graft in seven out of eight international studies carried out using similar methodology.

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