Electron Microscopic Study of Erythrocyte Receptors with Labeled Antisera to Membrane Components

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Abstract
Hemoglobin-free membranes and erythrocytes of group O, after reaction with ferritin-labeled rabbit antibody to purified virus receptor substance, were examined by electron microscopy. Antibody was found to bind specifically to discrete sites, in thin sections of cells and ghosts, as well as in negative contrast preparations of washed membranes. The distribution of reactive sites was similar to that described by others for ferritin-labeled isoantibody. The same antibody labeled with fluorescein reacted with washed membranes to give a granular type of fluorescence. The relationship of the virus receptor substance-reactive sites to those containing blood group antigens is discussed.

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