Possible Regulatory Role of Histamine in Human Platelet Function Examined by Thrombin-induced Serotonin Release

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Abstract
The influence of histamine on human platelet function was studied by thrombin-induced serotonin release. The thrombin-induced 3H-serotonin release was a rapid process which does not require external Ca. Histamine reduced the release of serotonin and the inhibition was abolished when H1- plus H2-antagonists were added together with histamine. H1- and H2-receptor stimulation was examined in 2 ways, by a combination of histamine with cimetidine or diphenhydramine and by the selective agonists 2-(2-pyridyl)-ethylamine and impromidine. In both instances H1- and H2-stimulation reduced the platelet serotonin release. These results suggest a regulatory role of histamine in the platelet function by stimulation of platelet H1- and H2-receptors.