Angiotensin II Stimulation of Prostaglandin Production in Cultured Human Vascular Endothelium
- 18 July 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 189 (4198) , 219-220
- https://doi.org/10.1126/science.1138377
Abstract
Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Prodcution is inhibited by indomethacin and stimulated by angiotensin II. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo.Keywords
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